References
A comprehensive bibliography of the clinical studies, mechanistic research, and intellectual property supporting the 5-FU + calcipotriene combination therapy.
Scientific Evidence
Supporting literature organized by evidence hierarchy
Primary Clinical Studies
Cunningham TJ, Tabacchi M, Eliane JP, et al.
Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy
J Clin Invest. 2017;127(1):106-116
Loranger N, et al.
Combined topical 5-fluorouracil and calcipotriene effectively treats superficial keratinocyte carcinomas: A retrospective cohort study from 2 academic centers
J Am Acad Dermatol. 2025;92(3):610-612
Intellectual Property
Rosenberg AR, et al.
Skin cancer precursor immunotherapy for squamous cell carcinoma prevention
JCI Insight. 2019;4(6):
Eisen DB, et al.
Guidelines of Care for the Management of Actinic Keratosis. Journal of the American Academy of Dermatology.
J Am Acad Dermatol 2021;84(4):e209-e233
Que SKT, Zwald FO, Schmults CD
Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging.
J Am Acad Dermatol 2018;78(2):237-247
Citation Information
The references listed on this page represent published peer-reviewed research, patent documents, and other scientific literature supporting the development of the 5-FU + calcipotriene combination therapy.
All information is provided for educational and informational purposes. This content does not constitute medical advice and should not replace consultation with qualified healthcare professionals.